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Turk Immunology Laboratory

Summary:

Research in the Turk Laboratory focuses on understanding how the immune system responds to progressive, poorly immunogenic cancers. We are interested in CD8+ effector and memory T cells that are primed by progressive tumors, and the CD4+CD25+ regulatory T cells that suppress these anti-tumor immune responses. Our overall goal is to generate durable protective immunity in tumor-bearing hosts, without the use of active immunization (vaccines). We focus on manipulating the host’s own immune milieu during tumor growth to induce long-lived protection against recurrent and metastatic disease.

Affiliations:

People:

Resources:

Databases

  • Mouse sheets ( Database )

    Database used to track breeding pairs.

Reagents

  • 2.43 ( Hybridoma cell line )

    Notes: Hybridoma: Anti-CD8

  • 3H3 ( Hybridoma cell line )

    Notes: Hybridoma: Anti-TPRKB

  • B16 ( Tumor-derived cell line )

  • B16-100K-V6 ( Tumor-derived cell line )

    Melanoma cell line.

  • B16-CII ( Tumor-derived cell line )

    Stably expresses of MHC Class II gene. Melanoma cell line.

  • B16-GMCSF ( Tumor-derived cell line )

    Stably expresses GM-CSF gene. Melanoma cell line.

  • B16-OVA ( Tumor-derived cell line )

    Melanoma cell line, exhibits stable expression of OVA gene.

  • B16-TTP ( Tumor-derived cell line )

    Melanoma cell line. Stably expresses TRP1 gene.

  • DTA-1 ( Hybridoma cell line )

    Hybridoma cell line, stably expresses anti-GITR mAb.

  • EL4 ( Tumor-derived cell line )

  • GK1.5 ( Hybridoma cell line )

    Notes: Hybridoma: Anti-CD4

  • HeLa ( Tumor-derived cell line )

  • JBRH ( Tumor-derived cell line )

    Melanoma cell line.

  • K562-A2.1 ( Tumor-derived cell line )

  • KB ( Tumor-derived cell line )

    Notes: KB is a subline of the ubiquitous KERATIN-forming tumor cell line HeLa

  • LiHa ( Tumor-derived cell line )

  • LLC ( Tumor-derived cell line )

  • PC61 ( Hybridoma cell line )

    Notes: Hybridoma: Anti-CD25

  • PK136 ( Hybridoma cell line )

    Notes: Hybridoma: Anti-NK

  • T2 ( Tumor-derived cell line )

    Notes: lymphoblast

  • TA99 ( Hybridoma cell line )

    Stably expresses anti-TA99 IgG2a mAb.

Software


Web Links:

Last updated: 2013-06-10T17:57:51.993-04:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016