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Clinical Pharmacology (CP)

Director: Lewis, Lionel

Summary:

The primary function of the Clinical Pharmacology Shared Resource (CPSR) is to support NCCC investigators in the design, analysis, and interpretation of clinical pharmacology objectives in preclinical and clinical studies, including chemoprevention and epidemiological studies. In addition to the biorepository function of our resource we also have bioanalytical hardware, computer hardware, and state-of-the-art commercial software programs for application to individual and population-based pharmacokinetic and pharmacodynamic modeling, and modeling drug in vitro and in vivo combination drug effects.

Affiliations:

People:

Resources:

Instruments

  • Dionex Ulitmate 3000 HPLC ( High performance liquid chromatography instrument )

    HPLC stack system with temperature controlled autosampler and column compartment. This instrument is connected to a TSQ Vantage LC-MS/MS.

  • MJ Research PTC-200 Thermo Cycler ( PCR instrument )

  • NanoDrop spectrophotometer ( Spectrophotometer )

    Full spectrum UV/Vis spectrophotometer.

  • Rainin fluorescence detector ( Fluorescence spectrometer )

  • ThermoFisher TSQ Vantage LC-MS -MS ( Mass spectrometer )

    Thermo Scientific* TSQ Vantage triple stage quadrupole mass spectrometer delivers the highest sensitivity with the lowest noise for the quantitative analysis of small molecules, peptides, biosimilars, and biologics.
    More signal and less noise provides better assay precision and accuracy. Combined with a robust new ion source, second generation (G2) ion optics and hyperbolic quadrupoles, the Thermo Scientific TSQ Vantage delivers the highest sensitivity with the lowest chemical noise.

    Note:
    Capabilities include ESI and APCI ionization, temperature controlled autosampler and LC column compartment

  • Varian UV/Vis detector and Rainin fluorescence detector ( Instrument )

    The Varian UV/Vis detector, manufactured by Agilent Technologies, is is a high performance liquid chromatography instrument.

    The Rainin fluorescence spectrometer model FL-1 is manufactured by Mettler-Toledo International.

  • Varian 210 HPLC pumps ( High performance liquid chromatography instrument )

  • Varian 410 HPLC autosampler ( High performance liquid chromatography instrument )

Reagents

Services

  • Bioanalytical service ( Service )

    Analyte measurement in biological samples by HPLC and LC-MS/MS

  • Biorepository service ( Material storage service )

    "Includes biorepository, sample collection/receipt, processing, logging, storage and mail out."

  • Modeling PK and PD and PK-PD ( Service )

    Pharmacokinetic and pharmacodynamic data modeling and analysis

  • Pharmacokinetic service ( Service )

    Consultation re study design for pharmacokinetic and pharmacodynamic study endpoints

Software

  • Calcusyn ( Software )

    Drug combination effect modeling-median effect analysis.

  • GraphPad Prism ( Software )

    Ligand binding analyses and data visualization. "GraphPad Prism is a powerful combination of basic biostatistics, curve fitting and scientific graphing in one comprehensive program....

    Designed for the practical scientist, Prism does not expect you to be a statistician. It guides you through each analysis - giving you as much help as you need - and tracks and organizes your work like no other program available."

  • P-Pharm ( Software )

    Descriptive statistical calculation software. Population pharmacokinetics.

  • SYSTAT ( Software )

    "SYSTAT is a versatile and comprehensive statistical software package. It employs a staggering range of powerful techniques to help conduct many types of research.

    Novice statistical users can use SYSTAT’s menu-driven interface to conduct simple analyses and produce beautiful 2D and 3D graphics for presentations or reports.

    Those in need of advanced analysis can use SYSTAT’s more sophisticated statistical routines, and create plots and charts that are instantly ready for publication. SYSTAT’s menu and command interfaces are interlinked, allowing users the option of whichever method works best for them."

  • XCalibur ( Software )

    Thermo Scientific™ Xcalibur™ software is a flexible Windows™-based data system that provides instrument control and data analysis for the entire family of Thermo Scientific™ mass spectrometers and related instruments. Utilized for Dionex UltiMate 3000 and TSQ Vantage instruments.


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Last updated: 2016-11-16T23:13:00.762-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016