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Fiering Laboratory

Summary:

This lab investigates the function of various cis-regulatory DNA elements in controlling transcription during mammalian development. Our present focus is on the beta-globin locus and in particular, how expression of one gene at the locus suppresses expression of other nearby genes.

We are also interested in mouse models of cancer and are developing novel mouse models. The influence of tobacco smoke exposure on the innate immune system is another area of research in the lab.

Affiliations:

People:

Resources:

Organisms and Viruses

  • B6.129-Kras[tm4Tyj] ( Mus musculus )

  • B6.C-Tg(CMV-cre)1Cgn.j ( Mus musculus )

    Transgenic, congenic; Hemizygote x Homozygote. http://jaxmice.jax.org/strain/006054.html x linked, small quantities available.

  • B6.Cg-Tg(Itgax-cre)1-1Reiz/J ( Mus musculus )

    Transgenic; inbred x heterozygote.

  • B6.FVB-Tg(Itgax-DTR/EGFP)57Lan/J ( Mus musculus )

    Transgenic; inbred x heterozygote.

  • B6;j-Tgn (ATCFLPe) 9205Dym ( Mus musculus )

    Small quantities available. e.g. http://jaxmice.jax.org/strain/003800.html Transgenic; Hemizygote x C57BL6.

  • Balb/c-Tgn(CMV-cre)1cgn ( Mus musculus )

    http://jaxmice.jax.org/strain/003465.html Transgenic; Hemizygote x Homozygote.

  • Bh1 neo ( Mus musculus )

    Knockout; chimera x C57BL6. PMID: 12525692 Mice currently stored as frozen embryos only (-/- x cd1). PMID: 17077320

  • Bh1 prd ( Mus musculus )

    knockout; chimera x C57BL6. PMID: 12525692 Mice currently stored as frozen embryos only (-/- x cd1). PMID: 17077320

  • D chd6 -/- ( Mus musculus )

    Knockout, and conditional KO. Chimera x C57BL6. KO x 129 and / or KO x CMV-cre.

  • D Hs2 c/d ( Mus musculus )

    Knockout, chimera x C57BL6. PMID: 16189270 Mice currently stored as frozen embryos (-/- x cd1), sperm from -/- frozen.

  • Ey hygro ( Mus musculus )

    Knockout, chimera x C57BL6. PMID: 12525692 Mice currently stored as frozen embryos (-/- x cd1), sperm from -/- frozen. PMID: 17077320

  • Eyprd ( Mus musculus )

    Knockout, chimera x C57BL6. PMID: 12525692 Mice currently stored as frozen embryos (-/- x cd1), sperm from -/- frozen. PMID: 17077320

  • FVB.129-Trp53[tm1Brn] ( Mus musculus )

    Inbred x heterozygote.

  • Myd88 KO ( Mus musculus )

    Knockout; inbred x heterozygote.

  • STOCK Brca1[tm2Cxd] ( Mus musculus )

    Knockout; inbred x heterozygote.

Reagents


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Last updated: 2012-10-04T10:46:46.891-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016