Vascular smooth muscle cell differentiation
1) Intimal hyperplasia and restenosis of stents is like a cancer of the arteries.
2)Connective tissue growth factor (CTGF) has recently been described as a novel profibrotic factor.
3) Polymer-based drug eluting stents have drastically reduced restenosis. Issues related to potential tradeoffs between efficacy and safety has received increasing attention due to increased risk of late thrombosis.
4) Sirtiuns have long been considered the anti-aging target. Since aging leads to a progressive decline in multiple organ systems, including the pancreas and heart it is not surprising that sirtiun benefits are now being realized in diabetes and CVD.