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Moseley Biochemistry Lab


We study the basic mechanisms that coordinate cell growth and division. At the heart of this coordination are signaling pathways that link cell polarity proteins with the core cell cycle machinery. We use a multi-disciplinary approach to identify these pathways, and then to understand how their activities are controlled by changes in cell size and shape. As many of these proteins are found at distinct sites in the plasma membrane, we have also become interested in the organizational principles that generate discrete compartments at the cell cortex. For this work, we use fission yeast cells as a model system because they allow us to combine a wide range of genetic, genomic, biochemical, and microscopy techniques. In addition, the basic cell polarity and cell cycle systems are well conserved between fission yeast and human cells, where they have important links to the generation of cancer.


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Last updated: 2011-11-29T11:28:10.583-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016