The Surgical Research Laboratory (SRL) is a bench laboratory and experimental OR research facility located in the Borwell building that originated more than 30 years ago.
The SRL is operated under the oversight of the Department of Surgery and is directed by P. Jack Hoopes DVM, PhD.
The SRL experimental animal operating suite includes state-of-the-art anesthesia delivery and monitoring, dedicated clinical fluoroscopy/angiography, ultrasound as well as a laser and ionizing radiation laboratory. The facility contains five permanent microsurgery operating microscope positions. Imaging modalities currently available for use include MRI, CT, PET, micro CT, ultrasound, fluoroscopy, bioluminescence and fluorescence imaging for large and small animal models. Expertise and instrumentation for endoscopy and laparoscopy are also available. An advanced intraoperative imaging facility has been funded and is under development.
Our bench laboratory plays an integral part in Dartmouth being designated as a Center of Cancer Nanotechnology Excellence (CCNE) with a grant from the National Cancer Institute (NCI). CCNEs are tasked with integrating nanotechnology into basic and applied cancer research in order to provide new solutions for the diagnosis and treatment of cancer. Our lab focus is on determining the optimal way to use alternating magnetic field-excited magnetic nanoparticle-mediated therapy to treat cancer, either as already confirmed in the breast/head and neck or as potentially unidentified multi-focal micro-metastases that remain after initial re-treatment. This project has both basic science and translational goals that will enhance the understanding of magnetic nanoparticle-mediated therapy, and also will explore crucial parameters that must be determined in order to design clinical trials.
Our lab specializes in working on small and large animal models for generating pre-clinical data.
10kW Heuttinger generator
25kW generator @ 167kHz
rodent and large animal anesthesia equipment
small and large animal anesthesia monitoring equipment
Fluoroscopic unit from GE.
all instruments needed to perform endoscopic procedures in large animal models
fibre-optic sensors for measuring temperature
all items necessary to do large animal laparoscopic studies
5 surgical microscope work stations
Large animal models for pre-clinical studiesJack Hoopes
developing small animal models for pre-clinical studies. Assist in surgical techniques.