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Miller Laboratory

Summary:

Research in the Miller Laboratory focuses on the translational application of knowledge of cell signaling pathways to therapeutics for breast cancer. Our work spans the spectrum of basic cancer biology, through translational studies in mouse models and human tissues, and interfaces with clinical trials. We use an array of methods and technologies both in our lab and through interaction with core facilities, including mammalian tissue culture, molecular analyses of gene and protein expression, gene expression microarrays, chromatin immunoprecipitation, next-generation DNA sequencing, bioinformatics, protein microarrays, mass spectrometry, mouse models, and live animal imaging.

Affiliations:

People:

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Reagents

  • BT-474 ( Tumor-derived cell line )

    notes: ER+, HER2+

  • BT-549 ( Tumor-derived cell line )

    notes: triple-negative

  • CAMA-1 ( Tumor-derived cell line )

    notes: ER+

  • COS-7 ( Cell line )

    notes: monkey fibroblast-like

  • HCC-1395 ( Tumor-derived cell line )

    notes: triple-negative

  • HCC-1428 ( Tumor-derived cell line )

    notes: ER+

  • HCC-1500 ( Tumor-derived cell line )

    notes: ER+

  • HCC-1806 ( Tumor-derived cell line )

    notes: triple-negative

  • HCC-1937 ( Tumor-derived cell line )

    notes: triple-negative

  • HCC-1954 ( Tumor-derived cell line )

    notes: HER2+

  • HCC-70 ( Tumor-derived cell line )

    notes: triple-negative

  • HEK-293 ( Immortalized embryonic cell line )

    notes: kidney cells

  • HEK-293T ( Immortalized embryonic cell line )

    notes: kidney cells
    293T cells are derived from 293 cells

  • HeLa ( Tumor-derived cell line )

  • IMR-90 ( Cell line )

    notes: primary fetal lung

  • LentiX ( Cell line )

    notes: HEK293 derivative, highly transfectable

  • MCF-10A ( Tumor-derived cell line )

    notes: immortalized epithelial

  • MCF-7 ( Tumor-derived cell line )

    notes: ER+

  • MDA-MB-134VII ( Tumor-derived cell line )

    notes: ER+ (barely sensitive to estradiol)

  • MDA-MB-157 ( Tumor-derived cell line )

    notes: triple-negative

  • MDA-MB-175VII ( Tumor-derived cell line )

    notes: ER+ (barely sensitive to estradiol)

  • MDA-MB-231 ( Tumor-derived cell line )

    notes: triple-negative

  • MDA-MB-361 ( Tumor-derived cell line )

    notes: ER+, HER2+

  • Phoenix ( Cell line )

    notes: HEK293 derivative to make retrovirus

  • SK-BR-3 ( Tumor-derived cell line )

    notes: HER2+

  • T47D ( Tumor-derived cell line )

    notes: ER+

  • ZR75-1 ( Tumor-derived cell line )

    notes: ER+


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Last updated: 2015-03-04T08:29:24.046-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016