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Compton Laboratory

Summary:

Work in this lab is aimed at understanding how chromosomes segregate efficiently during mitosis and meiosis in vertebrate cells. Using both in vitro and in vivo approaches, the assembly and function of the microtubule-based spindle is being dissected at the molecular level. This work has led to the characterization of both structural and motor proteins that are necessary for the organization of the microtubules into spindles during mitosis and meiosis. Current work is aimed at how this process is regulated during the cell cycle and at how these proteins coordinate chromosome movement during cell division.

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Reagents

  • 42MGBA ( Tumor-derived cell line )

    Notes: Glioblastoma cell line

  • A4573 ( Tumor-derived cell line )

    Notes: Ewing sarcoma

  • A549 ( Tumor-derived cell line )

    Notes: Lung carcinoma

  • CaLu ( Tumor-derived cell line )

    Notes: Lung adenocarcinoma

  • CB660 ( Tumor-derived cell line )

    Notes: Neural stem cell

  • DLD-1 ( Tumor-derived cell line )

    Notes: Colorectal adenocarcinoma

  • EKVX ( Tumor-derived cell line )

    Notes: Lung adenocarcinoma
    non-small-cell lung carcinoma cell line

  • GLiNS2 ( Tumor-derived cell line )

    Notes: Neural tumor stem cell

  • GNS144 ( Tumor-derived cell line )

    Notes: Neural tumor stem cell

  • GNS179 ( Tumor-derived cell line )

    Notes: Neural tumor stem cell

  • H4 ( Tumor-derived cell line )

    Notes: Neuroglioma

  • H460 ( Tumor-derived cell line )

    Notes: Lung carcinoma (large)

  • HCT116 ( Tumor-derived cell line )

    Notes: Colorectal carcinoma

  • HCT116 p53-/- ( Tumor-derived cell line )

    Notes: Colorectal carcinoma

  • HeLa ( Tumor-derived cell line )

  • Hop62 ( Tumor-derived cell line )

    Notes: Lung adenocarcinoma
    non-small-cell lung carcinoma cell line

  • HT1299 ( Tumor-derived cell line )

    Notes: Lung (NSCLC)

  • HT29 ( Tumor-derived cell line )

    Notes: Colon adenocarcinoma

  • IMR90 ( Primary fibroblast cell line )

    Notes: primary fetal lung

  • LoVo ( Tumor-derived cell line )

    Notes: Colon adenocarcinoma

  • LOX IMVI ( Tumor-derived cell line )

    Notes: Melanoma

  • MCF-7 ( Tumor-derived cell line )

    Notes: ER+

  • MDA-MB-231 ( Tumor-derived cell line )

    Notes: triple-negative

  • NRK ( Cell line )

    Notes: Kidney epithelium

  • PTK1 ( Cell line )

    Notes: Female Rat Kangaroo Kidney Epithelial Cells (PtK1 Line)

  • PTK2 ( Cell line )

  • RPE1 ( Tumor-derived cell line )

    Notes: Hygromycin resistant

  • SKMes-1 ( Tumor-derived cell line )

    Notes: Lung squamous cell carcinoma

  • SW440 ( Tumor-derived cell line )

    Notes: Colorectal adenocarcinoma

  • TK-10 ( Tumor-derived cell line )

    Notes: Renal cell carcinoma

  • U118 MG ( Tumor-derived cell line )

    Notes: Neuroglioma

  • U2-OS ( Tumor-derived cell line )

    Notes: Osteosarcoma

  • U251 ( Tumor-derived cell line )

    Notes: Glioblastoma cell line

  • U87 ( Tumor-derived cell line )

    Notes: Glioblastoma cell line


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Last updated: 2015-03-04T08:39:48.249-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016