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Kinlaw Laboratory

Summary:

Our research seeks to understand the peculiar metabolic needs of tumors, and how they adjust to them, with an eye toward exploiting tumor metabolism in the clinic. We have recently focused on the “addiction” of tumors, including breast cancers, to a supply of fatty acids. This has led to insights related to the regulation of lipid synthesis in tumors, and the ability to target it in preclinical systems and clinical trials. We recently found that tumors may not only synthesize fatty acids, but may also take them up from diet-derived lipoprotein particles in the circulation. Our laboratory has developed unique reagents to study these pathways, including novel antibodies and genetically engineered mice. We have also consistently focused on studies aimed to establish the relevance of our findings to actual human tumors, including breast and prostate cancers, sarcomas, and lymphomas, and are involved in clinical trials of the use of unusual fatty acids to manipulate these pathways inpatients. 0
Hanover NH 03755

People:

Resources:

Reagents

  • DU4475 ( Tumor-derived cell line )

    triple-negative; grows in suspension

  • LPS141 ( Tumor-derived cell line )

    dedifferentiated liposarcoma (DDLPS)

  • OCI-Ly3 ( Tumor-derived cell line )

    derived from a patient with diffuse large B-cell lymphoma; activated B-cell-like subtype


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Last updated: 2015-05-22T13:56:17.775-04:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016